The Proteintech Blog

Scanning electron micrograph of a human T-cell (Source: Wikimedia Commons, Original Source: NIH/NIAID.)
General News, News
0

PD-1 Blockade: Priming the Immune System to Combat Cancer

admin April 19, 2013

  The immune system’s role in cancer was a recurring topic at this year’s American Association of Cancer Research (AACR) Annual Meeting. From the outset of the conference, talks and poster presentations detailing how the immune response can be primed to combat cancer seemed ubiquitous; a reflection of the progress made in the field of… Continue Reading »

KRAS-Antibody-12063-1-AP-IHC33727
General News
0

PD-L1 and Lung Cancer Research: Pathways to Promising Immunotherapies

admin April 24, 2013

  Lung cancer remains a leading cause of cancer-related death worldwide due to its oft advanced stage at discovery, in combination with its difficult-to-treat and complex nature. Non-small cell lung cancer (NSCLC), for example, classifies some 85 per cent of lung cancer cases, and tumors in this category can harbor mutations in any of several… Continue Reading »

Scientist interviews
0

Protein Aggregation: Culprit or Custodian in Neurodegeneration? | Interview with Tiago Outeiro

admin April 4, 2013

Our resident blogger spoke to Professor Tiago Outeiro about his work in the field of neurodegeneration at the last German Neuroscience Society National Meeting in March. Professor Outeiro leads a team at the University of Goettingen Medical School, Germany, in the Department of Neurodegeneration and Restorative Research… Currently, neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s… Continue Reading »

DNA Repair. Source: Wikimedia Commons.
Antibody, Focus article, Guest blog
0

NEIL3 Antibody Used to Investigate Mechanisms of DNA Repair

admin April 2, 2013

  Guest post by Katie Griffiths Base excision repair is a crucial mechanism involved in DNA repair and protection. The process is initiated by DNA glycosylases, which recognize and cleave damaged or incorrectly paired bases. Owing to the importance of this process, considerable study has gone into understanding the cellular and molecular mechanisms involved, and… Continue Reading »

See you in Washington D.C for the 2013 installment of the Annual AACR Meeting
Proteintech News
0

What to See at The AACR Annual Meeting 2013 | Proteintech’s Top Picks

Deborah March 26, 2013

The last installment of the AACR Annual Meeting saw Proteintech celebrate its 10 year anniversary, its blog cover several conference sessions and interview prominent thought leaders in the field of cancer research. Whilst celebrations of Proteintech’s eleventh year of providing quality antibodies will be significantly more low-key, its resident blogger (yours truly) is looking forward… Continue Reading »

Immunohistochemical staining of paraffin-embedded testis tissue using Proteintech's PSAP antibody 10801-1-AP (10x lens).
Focus article, Guest blog, Product focus
0

PSAP Antibody Uncovers Potential Role of Prosaposin in Cancer Survival

admin March 26, 2013

Guest post by Kevin Measor Prosaposin or PSAP, a glycoprotein encoded by the PSAP gene, can be cleaved into four products: saposins A, B, C, and D. All four are important for the hydrolysis of sphingolipids ― compounds known to play an important role in signal transmission and cell recognition.  Mutations in the PSAP gene… Continue Reading »

Intermediate magnification micrograph of hepatocellular carcinoma, the most common form of primary liver cancer. Source: Wikimedia Commons, Author: Nephron.
Focus article, Guest blog
0

Tracking Cancer Vacularization and Progression with Proteintech’s Icam-1 Antibody

admin March 22, 2013

    Guest Post by Caroline Wood Icam-1 (CD54) is a long established member of the immunoglobulin superfamily, expressed as a glycosylated transmembrane protein in leukocytes and endothelial cells. A key molecule in cell adhesion, it interacts with integrins such as LFA-1 and Mac-1 to stabilize cell-cell interactions. For example, it facilitates the passage of… Continue Reading »

Immunohistochemical detection of JC virus protein (brown staining) in a brain biopsy (glial cells infected with PML). Source: Wikimedia Commons, Author: Marvin 101
Focus article, Guest blog, Product focus
0

BAG3 Antibody | Research Applications: from Muscular Dystrophies to Viral Infections

admin March 19, 2013

Guest post by Kate Campion Bcl2-associated athanogene (BAG3) (also known as CAIR-1) is a pleiotropic co-chaperone protein that is capable of activating multiple intracellular pathways. First identified as an anti-apoptotic protein, BAG3 has since been implicated in protein degradation via chaperone-mediated autophagy, CNS development, muscular dystrophies and neuropathies, the progress of viral infections, adhesion and… Continue Reading »

CiteAB
Learning Centre, News, Proteintech News
0

New Antibody Search Engine: CiteAb

admin March 18, 2013

Proteintech is working with a new antibody search engine called CiteAb to ensure antibodies are easy to find and that researchers can quickly see where they have been cited in the past. CiteAb lists over 800,000 antibodies from 50 companies, along with the publications that cite them. CiteAb is the world’s largest independent citation-ranked antibody… Continue Reading »

Immunohistochemical staining of paraffin-embedded human lung cancer using KEAP1 Antibody 10503-2-AP (10x lens).
Focus article, Guest blog, Product focus
0

NSCLC Research: Anti-Keap1 Antibody Helps Uncover Target’s Biomarker Potential

admin March 6, 2013

Guest post by Katie Griffiths Kelch-like ECH-associated protein 1 (Keap1) is a crucial substrate adapter protein for the Cul3-RBX E3 ubiquitin ligase complex, and a key regulator of the Nrf2 cytoprotective pathway. Under normal conditions, levels of Nrf2 are constantly regulated by rapid ubiquitination and proteasomal degradation; thus the antioxidant response is continually suppressed. However,… Continue Reading »

Login to your account

Can't remember your Password ?

Register for this site!