Antibodies Relevant to New Breast Cancer Data
admin May 9, 2012
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PDFIn April the results of a large study into breast cancer genetics were published in Nature. This ground breaking study revealed at least 10 genetically distinct subtypes of the disease, illuminating that breast cancer heterogeneity is more complex than thought initially. This article describes some of the antibodies available in the Proteintech catalog in the context* of some of the findings…
Deletions in the MTAP gene identify it as novel breast cancer gene…
MTAP - 11475-1-AP – rabbit polyclonal – ELISA, WB, IHC
CCND1 and PPP2R1B were identified as two subtype specific drivers of breast cancer in the 11q13/14 cis-acting subgroup known as “IntClust 2″…
CCND1 – 60186-1-Ig – mouse monoclonal – ELISA, WB
PPP2R1B – 12621-1-AP – rabbit polyclonal – ELISA, WB
An ER-positive subgroup composed of 11q13/14 cis-acting luminal tumors showed several known and putative driver genes in this chromosomal region; those available in the Proteintech catalog…
CCND1 - as above
PAK1 – 51137-1-AP – rabbit polyclonal – ELISA, WB, IHC
Immunohistochemistry of paraffin-embedded stomach cancer using PAK1 antibody 51137-1-AP (under 40x lens)
Numerous signalling molecules, transcription factors and cell division genes were found associated with a subset of basal cancers harboring chromosome 5q deletions, including alterations in…
AURKB – 60098-1-Ig – mouse monoclonal – ELISA, WB
BCL2 – 12789-1-AP – rabbit polyclonal - ELISA, WB, IHC
BCL2 – 60178-1-Ig – mouse monoclonal – ELISA, WB
CDC20 – 10252-1-AP – rabbit polyclonal – ELISA, WB
CDC45 – 15678-1-AP – rabbit polyclonal - ELISA, WB
CHEK1 – 65016-1-Ig – mouse monoclonal - ELISA, WB, IHC
FOXM1 – 13147-1-AP – mouse monoclonal – ELISA, WB
HDAC2 – 12922-3-AP – rabbit polyclonal - ELISA, WB, IHC, IF
IGF1R – 20254-1-AP – rabbit polyclonal - ELISA, WB, IP
KIFC1 - 20790-1-AP – rabbit polyclonal - ELISA, WB, IF
Immunofluorescence analysis of Hela cells using KIFC1 antibody 20790-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
MTHFD1L - 16113-1-AP – rabbit polyclonal - ELISA, WB, IHC
RAD51AP1 - 11255-1-AP – rabbit polyclonal – ELISA, WB
UBE2C - 12134-2-AP – rabbit polyclonal - ELISA, WB, IHC
“IntClust 5″ consist of the ERBB2-amplified cancers, composed of HER2-enriched (ER-negative) cases and luminal (ER-positive) cases…
ERBB2 (HER2) p185-specific – 18299-1-AP – ELISA, WB, IHC
ESR1 - 21244-1-AP – rabbit polyclonal – ELISA, WB
ESR2 - 60197-1-Ig – mouse monclonal – ELISA, WB
ESR2 - 14007-1-AP – rabbit polyclonal – ELISA, WB, IHC
rare but potentially significant events were found including amplifications in…
IGF1R – as above
KRAS - 12063-1-AP – rabbit polyclonal – ELISA, WB, IHC
EGFR - 18986-1-AP – rabbit polyclonal – ELISA, WB, IF
WB result using anti-EGFR (18986-1-AP) and loading different cell lysates.
…And homozygous deletions in…
BRCA2 - 19791-1-AP – rabbit polyclonal – ELISA, WB
RB1 - 10048-2-Ig – rabbit polyclonal – ELISA, WB, IHC
SMAD4 - 10231-1-AP – rabbit polyclonal – ELISA, WB
SMAD4 - 60182-1-Ig -mouse monoclonal – ELISA, WB
NCOR1 - 20018-1-AP – rabbit polyclonal – ELISA, WB, IHC
To view the entire Proteintech catalog visit www.ptglab.com
*Speech bubbles do not contain direct quotes from the referenced manuscript, they are brief summaries of several of its findings.