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An SMN targeted antibody, anti-SMN2, used for IHC staining
Focus article
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Focus on SMN – Survival of Motor Neuron Protein

admin June 12, 2013

Survival of motor neuron (SMN) protein — encoded by the SMN1 gene — is involved in the assembly of small nuclear ribonucleic particles or snRNPs (pronounced snurps): essential components of the spliceosome [1]. Defects in the SMN1 gene causes widespread aberrations in gene splicing; to which spinal motor neurons seem especially vulnerable [2]. The protein also functions… Continue Reading »

The 11th ISSCR Annual Meeting will be held in Boston next week. (Photo: Nelson48 via Wikimedia Commons)
Events
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ISSCR Annual Meeting: Proteintech’s Top Picks

admin June 6, 2013

Are you planning your itinerary for 2013 ISSCR Annual Meeting starting next Wednesday in Boston? Proteintech’s resident blogger provides a breakdown of the general program and gives recommendations for what to see whilst you’re at this year’s meeting… Wednesday June 12 The Presidential Symposium This session is definitely a must-attend. Not only does it open… Continue Reading »

A brain showing degeneration of the frontal lobe. Source: WIkimedia Commons
Latest publications, News, Product focus, Research focus
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TDP-43 Antibody Recommended for “Gold Standard” FTLD Diagnosis

admin May 28, 2013

Proteintech’s TDP-43 antibody (10782-2-AP) is applied in wide range of research into neurological conditions, such as Alzheimer’s and Parkinson’s disease, frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Since its involvement in the identification of TDP-43 as the “mystery”, ubiquitinated protein aggregate in a proportion of FTD and ALS cases (Neumann et al. Science 2006), this… Continue Reading »

KRAS-Antibody-12063-1-AP-IHC33727
General News
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PD-L1 and Lung Cancer Research: Pathways to Promising Immunotherapies

admin April 24, 2013

  Lung cancer remains a leading cause of cancer-related death worldwide due to its oft advanced stage at discovery, in combination with its difficult-to-treat and complex nature. Non-small cell lung cancer (NSCLC), for example, classifies some 85 per cent of lung cancer cases, and tumors in this category can harbor mutations in any of several… Continue Reading »

Scanning electron micrograph of a human T-cell (Source: Wikimedia Commons, Original Source: NIH/NIAID.)
General News, News
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PD-1 Blockade: Priming the Immune System to Combat Cancer

admin April 19, 2013

  The immune system’s role in cancer was a recurring topic at this year’s American Association of Cancer Research (AACR) Annual Meeting. From the outset of the conference, talks and poster presentations detailing how the immune response can be primed to combat cancer seemed ubiquitous; a reflection of the progress made in the field of… Continue Reading »

Scientist interviews
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Protein Aggregation: Culprit or Custodian in Neurodegeneration? | Interview with Tiago Outeiro

admin April 4, 2013

Our resident blogger spoke to Professor Tiago Outeiro about his work in the field of neurodegeneration at the last German Neuroscience Society National Meeting in March. Professor Outeiro leads a team at the University of Goettingen Medical School, Germany, in the Department of Neurodegeneration and Restorative Research… Currently, neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s… Continue Reading »

DNA Repair. Source: Wikimedia Commons.
Antibody, Focus article, Guest blog
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NEIL3 Antibody Used to Investigate Mechanisms of DNA Repair

admin April 2, 2013

  Guest post by Katie Griffiths Base excision repair is a crucial mechanism involved in DNA repair and protection. The process is initiated by DNA glycosylases, which recognize and cleave damaged or incorrectly paired bases. Owing to the importance of this process, considerable study has gone into understanding the cellular and molecular mechanisms involved, and… Continue Reading »

Immunohistochemical staining of paraffin-embedded testis tissue using Proteintech's PSAP antibody 10801-1-AP (10x lens).
Focus article, Guest blog, Product focus
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PSAP Antibody Uncovers Potential Role of Prosaposin in Cancer Survival

admin March 26, 2013

Guest post by Kevin Measor Prosaposin or PSAP, a glycoprotein encoded by the PSAP gene, can be cleaved into four products: saposins A, B, C, and D. All four are important for the hydrolysis of sphingolipids ― compounds known to play an important role in signal transmission and cell recognition.  Mutations in the PSAP gene… Continue Reading »

Intermediate magnification micrograph of hepatocellular carcinoma, the most common form of primary liver cancer. Source: Wikimedia Commons, Author: Nephron.
Focus article, Guest blog
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Tracking Cancer Vacularization and Progression with Proteintech’s Icam-1 Antibody

admin March 22, 2013

    Guest Post by Caroline Wood Icam-1 (CD54) is a long established member of the immunoglobulin superfamily, expressed as a glycosylated transmembrane protein in leukocytes and endothelial cells. A key molecule in cell adhesion, it interacts with integrins such as LFA-1 and Mac-1 to stabilize cell-cell interactions. For example, it facilitates the passage of… Continue Reading »

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