The Proteintech Blog

Category Archives: Focus article

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What Can We Learn by Studying ALS in a Dish?

admin May 21, 2014

  By Ashley Juavinett We typically think of disease as a systemic problem – for example, a person with amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) gradually loses the ability to move, indicating an underlying issue with motor systems. More recently, we have begun to consider diseases in a genetic light, noting that diseases… Continue Reading »

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C9ORF72 and Neurodegeneration: Where Are We Now?

admin May 21, 2014

   By Deborah Grainger In the Autumn of 2011, one of the biggest discoveries in the overlapping fields of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) and frontotemporal dementia (FTD) research was published in Neuron in two separate papers (DeJesus‑Hernandez et al. 2011, Renton et al. 2011). The findings, reported by independent groups, describe… Continue Reading »

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mRNA Methylation and the Circadian Clock: A New Role for an Old Modification

admin May 11, 2014

  Proteintech Guest Blogger Toryn Poolman, a circadian researcher based at the University of Manchester, talks us through one of the latest discoveries in the world of circadian biology. The paper appeared in the journal Nature and featured several Proteintech antibodies… espite my current postdoc position in the field of circadian biology, believe it or… Continue Reading »

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Immunoprecipitation Focus

admin March 21, 2014

    By Simon Hackett Immunoprecipitation is technique used widely in bioresearch that involves precipitation of a protein target from solution using an antibody. Successful immunoprecipiation of proteins is partly dependent on the quality of the antibody utilized. The majority of Proteintech antibodies are raised against whole protein antigens rather than short sequences of synthetic… Continue Reading »

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Imaging a Hidden Universe | A Story of Stress Granules

Deborah January 10, 2014

  Nancy Kedersha is a researcher based at Harvard Medical School and director of a confocal microscopy facility at the Brigham and Women´s Hospital in Boston, MA. A pioneer in the field of stress granule research, she was one of the very first to discover these dynamic structures, and to show that they form in… Continue Reading »

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Focus on Interleukin-18 (IL-18)

admin August 6, 2013

  By Melissa Fletcher Interleukin-18 (IL-18) is an inflammatory cytokine that plays multiple roles within the immune system, and much research is being undertaken to exploit the potentially therapeutic effects of this cytokine. IL-18 belongs to the IL-1 cytokine superfamily, beginning existence as pro-IL-18, an  ‘immature’, inactive 23 kDa protein. Pro-IL-18 is cleaved into active… Continue Reading »

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COMT antibody focus: Urinary exosomes used to identify novel kidney proteins

admin July 2, 2013

Proteintech’s rabbit polyclonal Catechol O-methyltransferase (COMT) antibody features in new research published in the Journal of Proteomics. All epithelial cells are now known to produce exosomes, and renal epithelial cells – including podocytes and the tubular epithelium – are no exception. Moreover, the urinary exosomes they release could be of great pathophysiological importance as they… Continue Reading »

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