The Proteintech Blog

Category Archives: Guest blog

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Ebola: Potential Molecular Targets for Drug Development

admin December 2, 2014

  By Simon Hackett Yesterday, December 1, marked exactly one year since the start of the Ebola outbreak – the viral epidemic currently sweeping West Africa that has claimed 5000 deaths to date. The WHO has recently described the epidemic as “the most severe acute public health emergency seen in modern times.”1 In recent months, the… Continue Reading »

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What Can We Learn by Studying ALS in a Dish?

admin May 21, 2014

  By Ashley Juavinett We typically think of disease as a systemic problem – for example, a person with amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) gradually loses the ability to move, indicating an underlying issue with motor systems. More recently, we have begun to consider diseases in a genetic light, noting that diseases… Continue Reading »

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mRNA Methylation and the Circadian Clock: A New Role for an Old Modification

admin May 11, 2014

  Proteintech Guest Blogger Toryn Poolman, a circadian researcher based at the University of Manchester, talks us through one of the latest discoveries in the world of circadian biology. The paper appeared in the journal Nature and featured several Proteintech antibodies… espite my current postdoc position in the field of circadian biology, believe it or… Continue Reading »

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The Glucocorticoid Receptor: Offering New Insight into Triple Negative Breast Cancer

admin December 12, 2013

  By Toryn Poolman The nuclear hormone receptor (or simply nuclear receptor or NR) family is a reasonably unfamiliar grouping of individually well-known proteins. You may be familiar with some of the 45 members of this family: the testosterone, progesterone and estrogen receptors for example. They are all structurally similar but bind a range of… Continue Reading »

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AMPA Receptor Trafficking Shapes the Synapse

admin October 23, 2013

  By Simon Hackett Retinal ganglion cells (RGCs) are neurons located near the ganglionic cell layer of the retina. These cells receive impulses from photoreceptor cells via bipolar and amacrine cells mediated by AMPA-class glutamate receptors (AMPA receptors). Two types of these receptors exist: receptors lacking GluA2 subunits, permeable to calcium ions, and those with a… Continue Reading »

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Olfactory Ensheathing Cells Promote Synaptogenesis

admin October 14, 2013

  By Simon Hackett Recent work by Yang et al. showing the importance of olfactory ensheathing cells (OECs) in promoting synaptogenesis and neurite growth also makes use of Proteintech antibody anti-Lamin B1. The paper, published in Cell Molecular Neurobiology, showed that OECs, a type of macroglial cell ensheathing olfactory neurons, were able to promote synaptogenesis… Continue Reading »

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Focus on Interleukin-18 (IL-18)

admin August 6, 2013

  By Melissa Fletcher Interleukin-18 (IL-18) is an inflammatory cytokine that plays multiple roles within the immune system, and much research is being undertaken to exploit the potentially therapeutic effects of this cytokine. IL-18 belongs to the IL-1 cytokine superfamily, beginning existence as pro-IL-18, an  ‘immature’, inactive 23 kDa protein. Pro-IL-18 is cleaved into active… Continue Reading »

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PSAP Antibody Uncovers Potential Role of Prosaposin in Cancer Survival

admin March 26, 2013

Guest post by Kevin Measor Prosaposin or PSAP, a glycoprotein encoded by the PSAP gene, can be cleaved into four products: saposins A, B, C, and D. All four are important for the hydrolysis of sphingolipids ― compounds known to play an important role in signal transmission and cell recognition.  Mutations in the PSAP gene… Continue Reading »

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Tracking Cancer Vascularization and Progression with Proteintech’s Icam-1 Antibody

admin March 22, 2013

    Guest Post by Caroline Wood Icam-1 (CD54) is a long established member of the immunoglobulin superfamily, expressed as a glycosylated transmembrane protein in leukocytes and endothelial cells. A key molecule in cell adhesion, it interacts with integrins such as LFA-1 and Mac-1 to stabilize cell-cell interactions. For example, it facilitates the passage of… Continue Reading »

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