The Proteintech Blog

Category Archives: Product focus

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Antibodies for Stress Granule Research

admin January 10, 2014

    Eukaryotic cells have evolved sophisticated strategies to combat a barrage of cellular stresses. Under stress, a cell’s main priority is to conserve energy and divert the rest toward survival, and where possible, recovery. Stress granules help by limiting protein production to just the essential proteins needed for survival. They act as foci of… Continue Reading »

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AMPA Receptor Trafficking Shapes the Synapse

admin October 23, 2013

  By Simon Hackett Retinal ganglion cells (RGCs) are neurons located near the ganglionic cell layer of the retina. These cells receive impulses from photoreceptor cells via bipolar and amacrine cells mediated by AMPA-class glutamate receptors (AMPA receptors). Two types of these receptors exist: receptors lacking GluA2 subunits, permeable to calcium ions, and those with a… Continue Reading »

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PSAP Antibody Uncovers Potential Role of Prosaposin in Cancer Survival

admin March 26, 2013

Guest post by Kevin Measor Prosaposin or PSAP, a glycoprotein encoded by the PSAP gene, can be cleaved into four products: saposins A, B, C, and D. All four are important for the hydrolysis of sphingolipids ― compounds known to play an important role in signal transmission and cell recognition.  Mutations in the PSAP gene… Continue Reading »

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BAG3 Antibody | Research Applications: from Muscular Dystrophies to Viral Infections

admin March 19, 2013

Guest post by Kate Campion Bcl2-associated athanogene (BAG3) (also known as CAIR-1) is a pleiotropic co-chaperone protein that is capable of activating multiple intracellular pathways. First identified as an anti-apoptotic protein, BAG3 has since been implicated in protein degradation via chaperone-mediated autophagy, CNS development, muscular dystrophies and neuropathies, the progress of viral infections, adhesion and… Continue Reading »

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NSCLC Research: Anti-Keap1 Antibody Helps Uncover Target’s Biomarker Potential

admin March 6, 2013

Guest post by Katie Griffiths Kelch-like ECH-associated protein 1 (Keap1) is a crucial substrate adapter protein for the Cul3-RBX E3 ubiquitin ligase complex, and a key regulator of the Nrf2 cytoprotective pathway. Under normal conditions, levels of Nrf2 are constantly regulated by rapid ubiquitination and proteasomal degradation; thus the antioxidant response is continually suppressed. However,… Continue Reading »

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Speech and Language Associated Genes: An Overview

admin March 1, 2013

The human capacity for vocal communication is unrivaled throughout the animal kingdom, though our genetic make-up only differs from our closest relatives by a percent or two. Researchers are beginning to unravel the neurogenetic pathways that enable this unparalleled capability for speech. Initial clues have been unearthed in the identification of genes associated with developmental… Continue Reading »

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MEF2C Antibody Features in Nature Biotechnology

admin February 26, 2013

Myocyte-specific enhancer factor 2, encoded by the MEF2C gene, is a well-established transcription factor involved in skeletal, cardiac and smooth muscle cell development. More recently, its role in brain development and function has also entered the research spotlight; the importance of MEF2C has been demonstrated in neural stem cells (NSCs), and by the observation of… Continue Reading »

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