The Proteintech Blog

Category Archives: Product focus

Immunohistochemical staining of paraffin-embedded testis tissue using Proteintech's PSAP antibody 10801-1-AP (10x lens).
Focus article, Guest blog, Product focus
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PSAP Antibody Uncovers Potential Role of Prosaposin in Cancer Survival

admin March 26, 2013

Guest post by Kevin Measor Prosaposin or PSAP, a glycoprotein encoded by the PSAP gene, can be cleaved into four products: saposins A, B, C, and D. All four are important for the hydrolysis of sphingolipids ― compounds known to play an important role in signal transmission and cell recognition.  Mutations in the PSAP gene… Continue Reading »

Immunohistochemical detection of JC virus protein (brown staining) in a brain biopsy (glial cells infected with PML). Source: Wikimedia Commons, Author: Marvin 101
Focus article, Guest blog, Product focus
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BAG3 Antibody | Research Applications: from Muscular Dystrophies to Viral Infections

admin March 19, 2013

Guest post by Kate Campion Bcl2-associated athanogene (BAG3) (also known as CAIR-1) is a pleiotropic co-chaperone protein that is capable of activating multiple intracellular pathways. First identified as an anti-apoptotic protein, BAG3 has since been implicated in protein degradation via chaperone-mediated autophagy, CNS development, muscular dystrophies and neuropathies, the progress of viral infections, adhesion and… Continue Reading »

Immunohistochemical staining of paraffin-embedded human lung cancer using KEAP1 Antibody 10503-2-AP (10x lens).
Focus article, Guest blog, Product focus
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NSCLC Research: Anti-Keap1 Antibody Helps Uncover Target’s Biomarker Potential

admin March 6, 2013

Guest post by Katie Griffiths Kelch-like ECH-associated protein 1 (Keap1) is a crucial substrate adapter protein for the Cul3-RBX E3 ubiquitin ligase complex, and a key regulator of the Nrf2 cytoprotective pathway. Under normal conditions, levels of Nrf2 are constantly regulated by rapid ubiquitination and proteasomal degradation; thus the antioxidant response is continually suppressed. However,… Continue Reading »

The Protein Foxp2 is necessary for normal speech and language development in humans. However, there are many other genes involved in the neuroprocessing and motor abilities associated with speech and language. Contemporary research is uncovering such targets. Source: Wikimedia Commons, Author: Carles Garcia-Roca
General News, Product focus
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Speech and Language Associated Genes: An Overview

admin March 1, 2013

The human capacity for vocal communication is unrivaled throughout the animal kingdom, though our genetic make-up only differs from our closest relatives by a percent or two. Researchers are beginning to unravel the neurogenetic pathways that enable this unparalleled capability for speech. Initial clues have been unearthed in the identification of genes associated with developmental… Continue Reading »

Immunohistochemistry of paraffin-embedded lymphoma tissue using Proteintech's anti-MEF2C antibody 10056-1-AP (viewed under 40x lens).
Antibody, Antibody case studies, Product focus, Proteintech News
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MEF2C Antibody Features in Nature Biotechnology

admin February 26, 2013

Myocyte-specific enhancer factor 2, encoded by the MEF2C gene, is a well-established transcription factor involved in skeletal, cardiac and smooth muscle cell development. More recently, its role in brain development and function has also entered the research spotlight; the importance of MEF2C has been demonstrated in neural stem cells (NSCs), and by the observation of… Continue Reading »

ACTB-Antibody-60008-1-Ig-A305WB-e1343923586215-300x225
General News, Learning Centre, Product focus
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Western Blot Loading Control Antibodies

admin August 3, 2012

by Deborah Grainger+   The proteins and peptides that regularly serve as endogenous or internal controls may not always take center stage in your research, but they are indispensable to your conducting meaningful experiments and are essential for publication. The Western blot is an immunoassay that requires such controls as they are widely used for determining specific… Continue Reading »

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