Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease and remains incurable. It is pathologically characterized by the presence of Lewy bodies and cell loss in various brain regions, in particular dopaminergic neurons in the substantia nigra pas compacta. The average age of onset of Parkinson’s disease is between 60 and 80 years, and about 1% of the general population above the age of 65 years is affected. A distinct set of genes have emerged, whose dysfunctional regulation is strongly associated with the condition. These genes include α-synuclein, parkin, PINK1, DJ-1, LRRK2 and ATP13A2. Here we will focus on DJ-1′s role in Parkinson’s disease. Proteintech’s DJ-1 antibody is a rabbit polyclonal (11681-1-AP) raised against full-length protein antigen.
DJ-1 and Parkinson’s disease
DJ-1 has been shown to be enriched in the brain and peripheral tissues and is primarily cytoplasmically localized, with a small pool associated with the mitochondria. DJ-1 is a member of the THiJ/Pfpl/DJ1 superfamily and is thought to be involved in the oxidative stress response by acting as a redox-dependent chaperone. It has also been implicated in the regulation of apoptosis through the phosphoinositide-3 kinase – AKT pathway. This hypothesis is supported by evidence showing that RNAi knockdown of DJ-1a in Drosophila increased its sensitivity to oxidative stress that was reduced with increasedPI3K/Akt-signaling capacity. The mechanism of interaction between DJ-1 and the PI3K/Akt pathway, however, remains unknown. DJ-1 has been reported to interact with α-synuclein, parkin and PINK1. The cross-talk between PD-associated proteins is probably central to the establishment of PD pathology and the molecular consequences of such interaction remains far from being elucidated. Much remains to be discovered about the causal link between DJ-1 and Parkinson’s disease. For more information on our DJ-1 antibody or to find out about any of our other antibodies, visit www.ptglab.com