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Antibody, Events, Focus article, General News, Guest blog, Proteintech News, Research focus, Uncategorized
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ASCB 2012 mini-symposium review: “Cellular Stress, Protein Folding, and Diseases”

admin January 4, 2013

Our Guest Blogger, Dr. Lori Silverman, gives us her second instalment of the Annual ASCB meeting with this report on mini-symposium “Cellular Stress, Protein Folding, and Diseases” co-chaired by Nancy M Bonini (University of Pennsylvania/HHMI) and Andy Dillin (Salk Institute for Biological Studies/HHMI) Building on the mini-symposium, “Cell Biology of Neurodegeneration”, Tuesday’s Mini-symposium recapitulated various neurodegenerative diseases,… Continue Reading »

San Fran
Events, General News, Guest blog, News, Research focus, Uncategorized
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ASCB 2012 mini-symposium review: “Cell Biology of Neurodegeneration”

admin January 4, 2013

This year, we asked Dr. Lori Silverman, a Research Associate at the Department of Physiology, University of Toronto, to write a guest report for us on what happened at ASCB 2012. Lori has attended the meeting for a number of years and is a regular contributor to their annual Newsletter. Mini-symposium “Cell Biology of Neurodegeneration”… Continue Reading »

Cell culture in Petri dish
General News, News, Research focus
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Unlocking Human MND Models:Do Skin Cells Hold the Key?

admin November 30, 2012

A matter of decades ago, the idea of turning a humble skin cell into a live, firing nerve cell would have seemed impossible; perhaps deemed the result of reading too many science fiction novels. Yet in a paper published earlier this year in PNAS, an international collaboration of researchers has done exactly this — essentially… Continue Reading »

FUS Antibody 60160-1-Ig
Antibody, General News, Research focus
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FTLD and ALS: Exploring Their Differences with Proteintech Antibodies

Deborah October 1, 2012

Several Proteintech antibodies have recently appeared in an Acta Neuropathologica paper further distinguishing the pathomechanisms behind FTLD-FUS and ALS with FUS mutations (ALS-FUS) [1]. The paper results from an international collaboration of several labs — including those of neuropathology experts Manuela Neumann (Tübingen, Germany) and Ian Mackenzie (Vancouver, Canada). The work describes differences in the… Continue Reading »

IF result using FUS (60160-1-Ig) from the paper "FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations" courtesy of Manuela Neumann.
Ten Year Anniversary
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Best Newcomer

admin February 7, 2012

FUS For some time, a debate as to whether FUS (fused in sarcoma) causes neurodegenerative disease independently of TDP-43 or not has been underway. To help out this discussion, Proteintech developed a monoclonal FUS antibody (60160-1-Ig) to further distinguish the presence of FUS in pathological protein inclusions. You can find out what frontotemporal dementia (FTD)… Continue Reading »

News
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Proteintech TDP-43 antibody proves to be an effective tool in FTLD and ALS research

admin February 19, 2010

TDP-43 is the major disease protein in ubiquitin-positive frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS) (Neumann et al1). Pathological TDP-43 is hyper-phosphorylated, ubiquitinated and C-terminal truncated. This finding, published in Science in 2006, has stimulated much research interest in TDP-43 and Proteintech is proud to have produced the TDP-43 antibody (10782-2-AP) which has… Continue Reading »

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