The Proteintech Blog

biomarkers

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Tracking Cancer Vascularization and Progression with Proteintech’s Icam-1 Antibody

admin March 22, 2013

    Guest Post by Caroline Wood Icam-1 (CD54) is a long established member of the immunoglobulin superfamily, expressed as a glycosylated transmembrane protein in leukocytes and endothelial cells. A key molecule in cell adhesion, it interacts with integrins such as LFA-1 and Mac-1 to stabilize cell-cell interactions. For example, it facilitates the passage of… Continue Reading »

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Guest Post: Mesothelioma Research and Clinical Trials

admin May 21, 2012

Mesothelioma is a rare form of cancer that most often affects the lining of the pleura (lungs) and peritoneum (abdominal cavity). In almost all cases, pleural and peritoneal mesotheliomas are caused by exposure to asbestos. This aggressive disease remains difficult to diagnose and treat. As a result, most patients are diagnosed in later stages, and… Continue Reading »

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MTAP-ing into mesothelioma diagnostics

admin May 8, 2012

Proteintech’s anti-MTAP antibody (11475-1-AP) has appeared in several research papers detailing the potential diagnostic value of the methylthioadenosine phosphorylase (MTAP) protein. The latest paper to feature our MTAP antibody was published in Histopathology this month and describes the diagnostic value of detecting MTAP in a subset of mesothelioma. Malignant pleural mesothelioma (MPM) is an aggressive… Continue Reading »

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Guest Blog – The ADAM Family: Key to Breast Cancer Metastasis?

admin March 6, 2012

By Henry Stanley ADAM12, a member of the ADAM (‘a disintegrin and metalloprotease’) protein family, has piqued the interest of the breast cancer research community. Discovered more than a decade ago, ADAM12‘s role in many cellular and physiological processes is well established: from fertilization to neurogenesis. However, recent research using Proteintech Group antibodies is uncovering… Continue Reading »

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