The Proteintech Blog

cancer research

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NSCLC Research: Anti-Keap1 Antibody Helps Uncover Target’s Biomarker Potential

admin March 6, 2013

Guest post by Katie Griffiths Kelch-like ECH-associated protein 1 (Keap1) is a crucial substrate adapter protein for the Cul3-RBX E3 ubiquitin ligase complex, and a key regulator of the Nrf2 cytoprotective pathway. Under normal conditions, levels of Nrf2 are constantly regulated by rapid ubiquitination and proteasomal degradation; thus the antioxidant response is continually suppressed. However,… Continue Reading »

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Matrix Metalloproteinase Antibodies

admin March 6, 2012

The study of matrix metalloproteinases (MMPs) is highly relevant to cancer research, particularly in the area of metastasis. Secreted into the extracellular matrix (ECM), these zinc-dependent endopeptidases are capable of degrading many kinds of ECM protein and facilitating invasion and migration. Conversely they can also inhibit metastasis in certain scenarios. Proteintech has a collection of… Continue Reading »

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