The Proteintech Blog

FTLD

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FTLD and ALS: Exploring Their Differences with Proteintech Antibodies

Deborah October 1, 2012

Several Proteintech antibodies have recently appeared in an Acta Neuropathologica paper further distinguishing the pathomechanisms behind FTLD-FUS and ALS with FUS mutations (ALS-FUS) [1]. The paper results from an international collaboration of several labs — including those of neuropathology experts Manuela Neumann (Tübingen, Germany) and Ian Mackenzie (Vancouver, Canada). The work describes differences in the… Continue Reading »

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Best Newcomer

admin February 7, 2012

FUS For some time, a debate as to whether FUS (fused in sarcoma) causes neurodegenerative disease independently of TDP-43 or not has been underway. To help out this discussion, Proteintech developed a monoclonal FUS antibody (60160-1-Ig) to further distinguish the presence of FUS in pathological protein inclusions. You can find out what frontotemporal dementia (FTD)… Continue Reading »

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Proteintech TDP-43 antibody proves to be an effective tool in FTLD and ALS research

admin February 19, 2010

TDP-43 is the major disease protein in ubiquitin-positive frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS) (Neumann et al1). Pathological TDP-43 is hyper-phosphorylated, ubiquitinated and C-terminal truncated. This finding, published in Science in 2006, has stimulated much research interest in TDP-43 and Proteintech is proud to have produced the TDP-43 antibody (10782-2-AP) which has… Continue Reading »

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