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An Honorary Mention
admin February 7, 2012IDH1 Lenny Dang and colleagues reported that cancer-associated IDH1 mutation R132H gives IDH1 a new enzymatic capability in Nature in 2009. In this paper they show the enzyme becomes able to catalyze the NADPH-dependent reduction of α-ketoglutarate to 2-hydroxyglutarate (2HG). Supporting this finding, excess accumulation of 2HG is tightly linked to an elevated risk of malignant brain tumors in patients… Continue Reading »