The Proteintech Blog

lung cancer

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PD-L1 and Lung Cancer Research: Pathways to Promising Immunotherapies

admin April 24, 2013

  Lung cancer remains a leading cause of cancer-related death worldwide due to its often advanced stage at discovery, in combination with its difficult-to-treat and complex nature. Non-small cell lung cancer (NSCLC), for example, classifies some 85 per cent of lung cancer cases, and tumors in this category can harbor mutations in any of several… Continue Reading »

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NSCLC Research: Anti-Keap1 Antibody Helps Uncover Target’s Biomarker Potential

admin March 6, 2013

Guest post by Katie Griffiths Kelch-like ECH-associated protein 1 (Keap1) is a crucial substrate adapter protein for the Cul3-RBX E3 ubiquitin ligase complex, and a key regulator of the Nrf2 cytoprotective pathway. Under normal conditions, levels of Nrf2 are constantly regulated by rapid ubiquitination and proteasomal degradation; thus the antioxidant response is continually suppressed. However,… Continue Reading »

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RRM1: A potential biomarker of lung cancer drug responses

admin January 27, 2011

RRM1 (ribonucleotide reductase subunit MI) protein is the regulatory subunit of the heterodimeric enzyme, ribonucleotide reductase. In humans it is encoded by the RRM1 gene, located on chromosome segment 11p15.5. This region is significant in the development of non-small-cell lung cancer (NSCLC) as it is typically inactivated during NSCLC oncogenesis. More than 70% patients with… Continue Reading »

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