The Proteintech Blog

malignant gliomas

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Ion Channels Facilitate the Spread of Glioma

Deborah December 6, 2013

    By Deborah Grainger In the Neuroscience 2013 Special Lecture “Glioma: A Neurocentric Look at Cancer” Harald Sontheimer, at the climax of his talk, challenged neuroscientists to take a fresh look at brain cancer, to view it from the perspective of neuroscience instead of  from a  predominantly oncological one — the main thrust behind glioma research… Continue Reading »

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An Honorary Mention | IDH1

admin February 7, 2012

Lenny Dang and colleagues reported that cancer-associated IDH1 mutation R132H gives IDH1 a new enzymatic capability in Nature in 2009. In this paper they show the enzyme becomes able to catalyze the NADPH-dependent reduction of α-ketoglutarate to 2-hydroxyglutarate (2HG). Supporting this finding, excess accumulation of 2HG is tightly linked to an elevated risk of malignant brain tumors in patients with… Continue Reading »

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