The Proteintech Blog

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mTOR signaling pathway poster

admin August 17, 2010

mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate translation. The drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known as FRAP. When bound to the immunophilin binding protein FKBP12, rapamycin inhibits mTOR kinase activity and… Continue Reading »

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Apoptosis Signaling Pathway Poster Launched

admin August 11, 2010

Download our new Apoptosis Signaling Pathway Poster here Apoptosis, derived from the Greek word for “falling off” or “dropping off” (like leaves from a tree), is defined by distinct morphological and biochemical changes. These changes are mediated by a family of cysteine aspartic acid-specific proteases (caspases), which are expressed as inactive precursors or zymogens (pro-caspases)… Continue Reading »

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VEGF signaling pathway poster launched

admin August 6, 2010

Proteintech have just launched the latest addition to our downloadable poster collection: the VEGF signaling pathway. Vascular endothelial growth factor (VEGF) is a major regulator of new blood vessel growth and an important inducer of vascular permeability. VEGF binds the receptor VEGFR2 leading to a cascade of different signaling pathways, which result in the up-regulation… Continue Reading »

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VEGF signaling pathway

admin July 20, 2010

Vascular endothelial growth factor (VEGF) is a major regulator of new blood vessel growth and an important inducer of vascular permeability. VEGF (also designated as VEGF-A) is the founding member of a family of homodimeric glycoproteins that are structurally related to the platelet-derived growth factors (PDGF). This VEGF family of proteins binds selectively with different… Continue Reading »

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Neurotrophin Signaling Pathway Poster Launched

admin July 19, 2010

The neurotrophin family of signaling factors comprise nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophins NT-3 and NT-4. These factors are involved in the differentiation and survival of neural cells. The best characterized receptors for these trophic factors are the tropomyosin-related tyrosine kinase receptors TrkA, TrkB, and TrkC, and a member of… Continue Reading »

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