The Proteintech Blog

tdp-43

San Fran
Events, General News, Guest blog, News, Research focus, Uncategorized
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ASCB 2012 mini-symposium review: “Cell Biology of Neurodegeneration”

admin January 4, 2013

This year, we asked Dr. Lori Silverman, a Research Associate at the Department of Physiology, University of Toronto, to write a guest report for us on what happened at ASCB 2012. Lori has attended the meeting for a number of years and is a regular contributor to their annual Newsletter. Mini-symposium “Cell Biology of Neurodegeneration”… Continue Reading »

Cell culture in Petri dish
General News, News, Research focus
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Unlocking Human MND Models:Do Skin Cells Hold the Key?

admin November 30, 2012

A matter of decades ago, the idea of turning a humble skin cell into a live, firing nerve cell would have seemed impossible; perhaps deemed the result of reading too many science fiction novels. Yet in a paper published earlier this year in PNAS, an international collaboration of researchers has done exactly this — essentially… Continue Reading »

A case of FTLD with ubiquitin inclusions stained with 10782-2-AP showing dystrophic neurites (viewed under a 40X lens). Courtesy of Linda K. Kwong.
Antibody, General News
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Parkinson’s Disease Research Featuring Proteintech Antibodies

admin October 4, 2012

The Proteintech blog takes a look at three Proteintech antibodies and the supporting roles they have played in Parkinson’s disease research. TDP-43 Proteintech’s TDP-43 antibody (10782-2-AP) is used in a wide range of research into neurological conditions, and has recently appeared in Parkinsonism-related research in Neuroscience Letters. The authors examined brain tissues exhibiting α-synucleinopathy, i.e…. Continue Reading »

"Modeling the Mind": The cover of Science Magazine October 6th 2006 Photos: Rob Melnychu/Getty; Matthias Kulka/Corbis (taken from sciencemag.org)
Ten Year Anniversary
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Neuroscience Star

admin February 7, 2012

TDP-43 Staying with the subject of neuroscience and neurodegenerative disease for the moment, no top ten Proteintech list would be complete without our TDP-43 polyclonal antibody (10782-2-AP). The main reason for this of course is this antibody’s involvement in the original identification of TDP-43 as the “mystery” ubiquitinated protein aggregate in a proportion of FTD… Continue Reading »

News
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Proteintech TDP-43 antibody proves to be an effective tool in FTLD and ALS research

admin February 19, 2010

TDP-43 is the major disease protein in ubiquitin-positive frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS) (Neumann et al1). Pathological TDP-43 is hyper-phosphorylated, ubiquitinated and C-terminal truncated. This finding, published in Science in 2006, has stimulated much research interest in TDP-43 and Proteintech is proud to have produced the TDP-43 antibody (10782-2-AP) which has… Continue Reading »

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