Resident blogger Deb Grainger has taken a look at the achievements of Proteintech antibodies over the years and has picked her top ten. Not only does 2012 bring us the US Presidential Election, the Olympic Games and the Year of the Dragon (as well as a certain notorious date in the Mayan calendar), it is of particular… Continue Reading »
Marcksl1 This one’s an award for the history lovers and marks (or should that be Marcks?) the first sale of a pre-made antibody – which came in May 2002 with a vial of our Marcksl1-targeting polyclonal IgG (10002-2-AP). Marcksl, also known as MacMARCKS, is a member of the MARCKS family of specific protein kinase C (PKC) substrate… Continue Reading »
CSTF1 The first research paper to feature a Proteintech antibody appeared in The EMBO Journal on September 1st 2003. It reported on work done at Oxford University, UK investigating the production of the 3’ ends of pre-snRNAs (small nuclear RNAs). Our CSTF antibody (10064-2-AP) was of several used to identify known RNA cleavage factors bound to synthetic RNA… Continue Reading »
FUS For some time, a debate as to whether FUS (fused in sarcoma) causes neurodegenerative disease independently of TDP-43 or not has been underway. To help out this discussion, Proteintech developed a monoclonal FUS antibody (60160-1-Ig) to further distinguish the presence of FUS in pathological protein inclusions. You can find out what frontotemporal dementia (FTD)… Continue Reading »
SMN2 With the help of our SMN2 antibody, scientists at the Spinal Muscular Atrophy (SMA) Foundation, New York have developed a sandwich ELISA kit that measures the level of survival motor neuron (SMN) protein from blood serum samples. The researchers behind the kit utilized Proteintech’s SMN antibody (11708-1-AP) in the developmental process. It is hoped that this sandwich… Continue Reading »
TDP-43 Staying with the subject of neuroscience and neurodegenerative disease for the moment, no top ten Proteintech list would be complete without our TDP-43 polyclonal antibody (10782-2-AP). The main reason for this of course is this antibody’s involvement in the original identification of TDP-43 as the “mystery” ubiquitinated protein aggregate in a proportion of FTD… Continue Reading »
FKBPL Our winner from the field of oncology is FKBPL polyclonal antibody (10060-1-AP), used by the lab of Professor Tracy Robson at Queens University Belfast. The Robson group is finding ways to sensitize tumors to existing therapies such as chemotherapy and radiotherapy. With the help of our FKBPL antibody the Robson group has shown that high FKBPL levels in… Continue Reading »
LIN28 I’ve voted LIN28 (11724-1-AP) our stem cell star antibody as it is one of our best in this area and is often used as a stem cell marker (see image). It first appeared in a publication featuring in Nature Genetics in 2009, describing how LIN28, and homolog LIN28B, block let-7 microRNA (miRNAs) precursors from being processed… Continue Reading »
IFT88 Our IFT88 antibody (13967-1-AP) targets intraflagellar transport protein 88 which is required for primary cilium biogenesis. Despite being around for a few years now, this antibody has recently attracted a high amount of interest after featuring in a string of high-profile publications including Nature Genetics and Cell. This surge of interest, I think, correlates with the rapidly expanding… Continue Reading »
FAK Whilst our antibodies have featured in over 2,500 publications so far, I think our FAK antibody (12636-1-AP) deserves a mention here as it secured the 1000th such appearance of a Proteintech IgG. The paper appeared in Nature Cell Biology, and was another study looking at the biology and pathology of microRNAs (miRNAs). FAK – encoding the… Continue Reading »